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Moreover, GSH-independent roles of Gclc associated with its direct product-glutamylcysteine (-GluCys)might influence the downstream regulation of biosynthetic pathways of amino acids (and/or their transport) 119 in MZB and FoB

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Ex vivo assays, bridging the gap between in vitro and in vivo models, require future development of advanced cell culture systems such as 3D models and organ-on-a-chip platforms to better mimic human tissue complexity (Vitale et al., 2020)

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